SC GMaP Regional Conference

Regions 1 & 2

August 12th, 2014 | 8 AM -4 PM

Public Health Research Center

University of South Carolina

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Study Identifies New Molecular Features of Colorectal Cancer

Study Identifies New Molecular Features of Colorectal Cancer

CPTAC researchers report first large-scale integrated proteomic and genomic analysis 

Investigators from the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) 

 who comprehensively analyzed 95 human colorectal tumor samples, have determined how gene alterations 

identified in previous analyses of the same samples are expressed at the protein level. 

The integration of proteomic and genomic data, or proteogenomics, provides a more comprehensive 

view of the biological features that drive cancer than genomic analysis alone and may help identify the 

most important targets for cancer detection and intervention. 

The results of this study appeared online July 20, 2014, in Nature. 

The colorectal study produced several key findings:

• Measurements of messenger RNA abundance did not reliably predict protein abundance.
• The investigators were not surprised by this discordance, because many regulatory controls lie between RNA and protein expression. However, it did demonstrate that RNA analyses do not necessarily give a correct indication of protein levels. Most of the focal amplifications (increased amounts of certain chromosome segments) observed in the earlier genomic analyses of the same tumors did not result in corresponding elevations in protein level. Proteomic analyses indentified a few amplifications that had dramatic effects on protein levels and may represent potentially important targets for diagnosis or therapeutic intervention.
• Proteomics identified five colon cancer subtypes, including classifications that could not be derived from genomic data.
• Protein expression signatures for one ofthe subtypes indicated molecular characteristics associated with highly aggressive tumors with poor clinical outcome.

"This study provides the first clear demonstration that proteomics can help explain how genomic abnormalities drive cancer," said senior  said senior author of the study, Daniel C. Liebler, Ph.D, Director, Jim Ayers Institute for 

Precancer Detection and Diagnosis, Vanderbilt University School of Medicine. 

This study, by CPTAC investigators, was made possible because it utilized the same set of tumors that 

were genomically analyzed in 2012 by The Cancer Genome Atlas (TCGA).

"These findings show that by combining proteomic and genomic analyses, one is able to gain additional 

biological information for a disease," said Henry Rodriguez, Ph.D, M.B.A., 
Director of the Office of Cancer Clinical Proteomics Research, National Cancer Institute. 

Visit http://proteomcis.cancer.gov for more information.
Download data files, click here.

View data in an interactive gene network browser, click here.

If you've received this email from a colleague and would like to sign up to receive

regular email updates from the NCI Office of Cancer Clinical Proteomics Research directly,

go to http://proteomics.cancer.gov/global/emailsignup.

To unsubscribe from the NCI Proteomics News list, send a blank email to:

NCI-PROTEOMICS-NEWS-signoff-request@LIST.NIH.GOV.

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Maryland GMaP Regional Conference | June 19th, 2014

View Maryland GMaP Regional Conference (Regions 1 & 2) Presentations
Conference focus: Strengthening linkages within GMaP to address health disparities and advancing science by creating training opportunities for early/new stage investigators.

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Map of Research Institutions | Regions 1 and 2

GMaP R1R2 Member Network

Click on Google Map to access Interactive Map

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Cancer Health Disparities: Challenges and Opportunities

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JUNE 19th | GMaP Regions 1 & 2 Conference | Bethesda, Maryland

Save the Date!

June 19th, 2014

GMaP Regions 1 & 2 Conference

Bethesda, Maryland

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Register now

To book your hotel room at the Bethesda North Marriott please visit: https://resweb.passkey.com/Resweb.do?mode=welcome_ei_new&eventID=11483274

Funds are available for committee members to travel to one conference, and there are travel awards available for trainees. 

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7th Annual James Clyburn Health Disparities Lecture | April 11, 2014

https://twitter.com/CPCPUSC/status/454701448362618880/photo/1


http://www.sph.sc.edu/news/2014Clyburn-AwardRecipients.html

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NIH Presentations on BioSpecimens Collections & Repositories

View NIH Presentations on Biospecimens Collections & Repositories

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Twitter chat on Behavioral Sciences Careers in Academia | March 28th | 2 PM EST

Twitter chat on Behavioral Sciences Careers in Academia | March 28th | 2 PM EST

The Office of Behavioral and Social Sciences Research (OBSSR) at the National Institutes of Health will like to invite you to join the upcoming Twitter chat on Behavioral Sciences Careers in Academia. The panelists on this chat will be discussing and answering questions on applying for faculty positions in the fields of Behavioral Sciences, Psychology, Social Sciences, Public Health, and Epidemiology. This session will be live on Friday, March 28^th, 2014 from 2 – 3 pm EDT. Please join the conversation using #OBSSRchat. You may follow the stream of tweets at @NIHOBSSR or at http://twubs.com/obssrchat. You can find more information on the twitter chat at http://obssr.od.nih.gov/news_and_events/obssr_twitter_chats/index.aspx.  

The panelists on this chat are Marc Adams, PhD, MPH, Arizona State University, Vicki Johnson-Lawrence, PhD, MS, University of Michigan,  Robert Kaplan, PhD, MA, Director, NIH Office of Behavioral and Social Sciences Research (Former faculty at University of California, Los Angeles,  and  Karen McDonnell, PhD, George Washington University.

OBSSR is dedicated to the training and career development of the next generation. This series will highlight types of jobs available for persons with MA, MS, MPH, or PhDs in the fields of Behavioral Sciences, Psychology, Social Sciences, Public Health, and Epidemiology.  This is not a job fair. Rather it is an opportunity to explore different career paths; to understand the different responsibilities and expectations; and to hear advice on strategies for applying and for succeeding in the field.   

Please share this information with your members, social media community and anyone who will be interested in this topic. Below are sample tweets, Facebook post and graphics for sharing.

Twitter Posts

• Join @NIHOBSSR on 3/28, 2pET for a chat w/ faculty on Behavioral Sciences careers in academia http://go.usa.gov/KUGd  #OBSSRchat #careers
• Pursuing a career in behavioral sciences? Want to work as faculty? @OBSSR chats w/ faculty 3/28,2pET http://go.usa.gov/KUGd #obssrchat
   
  Facebook Post

• Pursuing a career in behavioral sciences, psychology and public health?  Are you interested in faculty positions in behavioral science?  Join the Office of Behavioral and Social Sciences Research and a panel of faculty on March 28, 2014 from 2-3pm EDT for a Twitter chat on Careers in Behavioral Sciences in Academia? Join the conversation using the hashtag #OBSSRchat. Follow @NIHOBSSR. Learn more – [http://go.usa.gov/KUGd]

Graphic

Thank you,

Nana Afari [C],

Web Manager, OBSSR

Building 31, B1C32

301-594-1205

Visit our website:  http://obssr.od.nih.gov 

Blog:  http://connector.obssr.od.nih.gov/ 

Connect with us: 

https://twitter.com/NIHOBSSR

https://www.facebook.com/OBSSR.NIH

https://www.facebook.com/NIHAdherenceNetwork

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Advocacy In Action: Communicating with Patients About Tissue Collection ...

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